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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPN6 All Species: 18.79
Human Site: S186 Identified Species: 37.58
UniProt: P29350 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P29350 NP_002822.2 595 67561 S186 G G L E T F D S L T D L V E H
Chimpanzee Pan troglodytes XP_001163468 596 67703 L188 G L E T F D S L T D L V E H F
Rhesus Macaque Macaca mulatta XP_001110915 597 67615 S188 G G S E T F D S L T D L V E H
Dog Lupus familis XP_543844 595 67669 S186 G G A E T F D S L T D L V E H
Cat Felis silvestris
Mouse Mus musculus P29351 595 67540 S186 G G S E T F D S L T D L V E H
Rat Rattus norvegicus P81718 613 69560 S188 G G S E T F D S L T D L V E H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519010 556 61792 L164 Y T Q Q Q G V L Q D R D G T I
Chicken Gallus gallus Q90687 593 67964 D188 V G G G E K F D S L T D L V E
Frog Xenopus laevis NP_001085766 594 68095 F188 D V G G G E R F D T L T D L L
Zebra Danio Brachydanio rerio NP_956254 589 66986 D186 D Q F D N L T D L V E H F K R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P29349 845 92957 R188 E L I D H Y K R N P M V E T C
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784121 533 60826 S140 G S Y L V R E S H S K P G D Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.9 97.8 96.1 N.A. 94.4 91 N.A. 68 54.2 58.3 64.7 N.A. 33.8 N.A. N.A. 43.3
Protein Similarity: 100 98.8 98.4 97.9 N.A. 98.1 94.9 N.A. 72.9 70.7 72 78.4 N.A. 46.9 N.A. N.A. 60.8
P-Site Identity: 100 6.6 93.3 93.3 N.A. 93.3 93.3 N.A. 0 6.6 6.6 6.6 N.A. 0 N.A. N.A. 13.3
P-Site Similarity: 100 13.3 93.3 93.3 N.A. 93.3 93.3 N.A. 6.6 13.3 6.6 26.6 N.A. 26.6 N.A. N.A. 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % C
% Asp: 17 0 0 17 0 9 42 17 9 17 42 17 9 9 0 % D
% Glu: 9 0 9 42 9 9 9 0 0 0 9 0 17 42 9 % E
% Phe: 0 0 9 0 9 42 9 9 0 0 0 0 9 0 9 % F
% Gly: 59 50 17 17 9 9 0 0 0 0 0 0 17 0 0 % G
% His: 0 0 0 0 9 0 0 0 9 0 0 9 0 9 42 % H
% Ile: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 9 % I
% Lys: 0 0 0 0 0 9 9 0 0 0 9 0 0 9 0 % K
% Leu: 0 17 9 9 0 9 0 17 50 9 17 42 9 9 9 % L
% Met: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % M
% Asn: 0 0 0 0 9 0 0 0 9 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 9 0 9 0 0 0 % P
% Gln: 0 9 9 9 9 0 0 0 9 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 9 9 9 0 0 9 0 0 0 9 % R
% Ser: 0 9 25 0 0 0 9 50 9 9 0 0 0 0 0 % S
% Thr: 0 9 0 9 42 0 9 0 9 50 9 9 0 17 0 % T
% Val: 9 9 0 0 9 0 9 0 0 9 0 17 42 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 0 9 0 0 9 0 0 0 0 0 0 0 0 9 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _